Laboratory for Tissue Engineering and Morphogenesis

Journal Articles


49. P Ray, AS Chin, KE Worley, J Fan, G Kuar, M Wu, and LQ Wan*, Intrinsic Cell Chirality Regulate Left-Right Symmetry Breaking During Cardiac Looping, Proceedings of National Academy of Sciences, pii: 201808052.


48. AS Chin, KE Worley, P Ray, G Kuar, J Fan, and LQ Wan*, Cell Chirality Revealed By Three-Dimensional Spontaneous Rotation, Proceedings of National Academy of Sciences, 115(18), pp.12188-12193,


47. A Abu-Hakmeh, AKM Fleck, and LQ Wan*, 2018. Temporal Effects of Cytokine Treatment on Lubricant Synthesis and MMP Activity of Fibroblast-like Synoviocytes, Journal of Tissue Engineering and Regenerative Medicine, epub ahead of print.


46. KE Worley, AS Chin, and LQ Wan*, 2018. Lineage-Specific Chiral Biases of Human Embryonic Stem Cells During Differentiation, Stem Cell International, Vol. 2018, 1848605.


45. J. Fan, P Ray, Y Lu, G Kaur, JJ Schwarz, and LQ Wan*, 2018. Cell chirality regulates intercellular junctions and endothelial permeability. Science Advances, 4, eaat2111. 10.1126/sciadv.aat2111.


44. KE Worley, J Rico-Varela, D Ho and LQ Wan*, 2018. Teratogen Screening with Human Pluripotent Stem cells. Integrative Biology, 10(9), pp491-501. (link)


43. J Rico-Varela, D Ho and LQ Wan*, 2018. In vitro Microscale Systems for Embryogenesis. Advanced Biosystems, 2 (6), 1700235. (link)


42. EY Sun, AKM Fleck, A Abu-Hakmeh, A Kotsakis, GR Leonard, and LQ Wan*, 2018. Cartilage Metabolism and Mechanics Modulated By Synovial Fluid Through Metalloproteinase Proteins, Annals of Biomedical Engineering, 46(6), pp810-818. (link)


41. J Li, L Miao, C Zhao, WM Shaikh Qureshi, D Shieh, H Guo, Y Lu, S Hu, A Huang, L Zhang, CL Cai, LQ Wan, H Xin, P Vincent, HA Singer, Y Zheng, O Cleaver, ZC Fan, and M Wu, 2017. CDC42 Is Required For Epicardial and Pro-epicardial Development By Mediating FGF Receptor Trafficking To The Plasma Membrane. Development, 144(9), pp1635-47. (link)


40. MJ Raymond, P Ray, G Kaur, P Haynes, M Fredericks, AV Singh, and LQ Wan*, 2017. Multiaxial Polarity Determines Individual Cellular and Nuclear Chirality, Cellular and Molecular Bioengineering, 10(1), pp 63-74. (link)


39. LQ Wan*, AS Chin, KE Worley, and P Ray, 2016. Cell Chirality: Emergence of Asymmetry From Cell Culture, Philosophical Transactions B, 371(1710). pii: 20150413. (link)


38. AE Abu-Hakmeh, A Kung, B Mintz, S Kamal, J Cooper, LX Lu, LQ Wan*,2016. Sequential Gelation of Tyramine Substituted Hyaluronic Acid Hydrogels Enhances Mechanical Integrity and Cell Viability, Medical & Biological Engineering & Computing, 54(12), pp. 1893-1902. (link)


37. MJ Raymond, P Ray, G Kaur, AV Singh, and LQ Wan*,2016. Cellular and Nuclear Alignment Analysis for Determining Epithelial Cell Chirality, Annals of Biomedical Engineering, 44(5), pp.1475-86. (link)


36. X Chen, Y Zhou, BK Zimmerman, L Wang, MH Santare, LQ Wan, and XL Lu, 2016. Determining Tension-Compression Nonlinear Mechanical Properties of Articular Cartilage from Indentation Testing. Annals of Biomedical Engineering, 4(4), pp.1148-58. (link)


35. AKM Fleck and LQ Wan*, 2015. Magnetic Resonance Imaging of Healthy, Diseased, and Regenerated Cartilage, Current Tissue Engineering, 4(2), pp. 111-121. (link)

34. Y Zhou, MA David, X Chen, LQ Wan, RL Duncan, L Wang and XL Lu, 2015. Effects of Osmolarity on the Spontaneous Calcium Signaling of In Situ Juvenile and Adult Articular Chondrocytes. Annals of Biomedical Engineering, 44(4), pp.1138-47. (link)


33. J Xie, T Owen, K Xia, AV Singh, E Tou, B Arduini, H Li, LQ Wan, B Callahan, and C Wang, 2015. Zinc Inhibits Hedgehog Autoprocessing: Linking Zinc Deficiency with Hedgehog Activation, J Biol Chem, 290(18), pp.11591-600. (link)


32. KE Worley, D Shieh, and LQ Wan*, 2015. Inhibition of Cell-Cell Adhesion Randomized Epithelial Chiral Morphogenesis on Micropatterned surfaces, integr Biol, 7(5), pp. 580-90.(link)


31. AV Singh, M Raymond, F Pace, A Certo, JM Zuidema, CA McKay, RJ Gilbert, XL Lu, and LQ Wan*, 2015. Astrocytes Increase ATP Exocytosis Mediated Calcium Signaling in Response to Microgroove Structures, Scientific Reports, 5: 7848. (link)


30. S Bhumiratana, RE Eton, SR Oungoulian, LQ Wan, GA Ateshian and Vunjak-Novakovic G, 2014. Large, Stratified, and Mechanically Functional Human Cartilage Grown in vitro by Mesenchymal Condensation, Proceedings of National Academy of Science, 111(19), pp. 6940-5. (link)


29. AE Abu-Hakmeh AE and LQ Wan*, 2014. High-Throughput Cell Aggregate Culture for Stem Cell Chondrogenesis, Methods Mol Biol, 1202:11-9. (link)


28. AV Singh, KK Mehta, K Worley, JS Dordick, RS Kane, and LQ Wan*, 2014. Carbon Nanotube-Induced Loss of Multicellular Chirality on Micropatterned Substrate Is Mediated by Oxidative Stress, ACS Nano, 8(3), pp. 2196-205. (link)


27. YS Zhang, A Sevilla, LQ Wan, IR Lemischka, G Vunjak-Novakovic, 2013. Patterning Pluripotency in Embryonic Stem Cells, Stem Cells, 31(9), pp.1806-15.(link)


26. LQ Wan*, K Ronaldson, M Guirguis, and G. Vunjak-Novakovic*, 2013. Micropatterning of Cells Reveals Chiral Morphogenesis, Stem Cell Research and Therapy, 4:24-31. (link)


25. K Worley, A Certo, and LQ Wan*, 2013. Geometry-Force Control of Stem Cell Fate, BioNanoScience, 3(1), pp. 43-51.(link)

24. NT Khanarian, J Jiang, LQ Wan, VC Mow, and HH Lu, 2012. A Hydrogel-Mineral Composite Scaffold for Osteochondral Interface Tissue Engineering, Tissue Engineering, 18(5-6), pp. 533-45.(link)

23. T Zhang, LQ Wan, A Marsano, R Maidhof, and G Vunjak-Novakovic, 2012. Chitosan-Collagen Based Channeled Scaffold for Cardiac Tissue Engineering, Journal of Tissue Engineering and Regenerative Medicine, 6(9), pp.748-756.(link)


22. LQ Wan and G Vunjak-Novakovic. Micropatterning Chiral Morphogenesis, 2011. Communicative & Integrative Biology, 4(6), pp. 748-756.(link)


21. Y Duan, Z Liu, J O'Neill, LQ Wan, DO Freytes, G Vunjak-Novakovic, 2011. Hydrogel Derived from Native Heart Matrix Induces Cardiac Differentiation of Human Embryonic Stem Cells Without Supplemental Growth Factors, Journal of Cardiovascular Translational Research, 4(5), pp. 605-15.(link)


20. LQ Wan, K Ronaldson, M Park, G Taylor, Y Zhang, JM Gimble, and G Vunjak-Novakovic, 2011. Micropatterned Mammalian Cells Exhibit Phenotype-Specific Left-Right Asymmetry, Proceedings of National Academy of Science, 108(30), pp. 12295-300.(link)

19. LQ Wan, J Jiang, DE Arnold, XE Guo, VC Mow, and HH Lu, 2011. Matrix Deposition Modulates Viscoelastic Shear Properties of Hydrogel-Based Engineered Cartilage Tissue, Tissue Engineering Part A, 17(7-8), pp.1111-22.(link)

18. AF Godier-Furnémont, TP Martens, MS Koeckert, LQ Wan, JJ Parks, K Arai, G Zhang, BJ Hudson, S Homma, and G Vunjak-Novakovic, 2011. Composite Scaffold Provides A Cell Delivery Platform For Cardiovascular Repair, Proceedings of National Academy of Science,108(19), pp. 7974-9.(link)

17. N Tandon, A Marsano, R Maidhof, LQ Wan, H Park, and G Vunjak-Novakovic, 2011. Optimization of Electrical Stimulation Parameters for Cardiac Tissue Engineering, Journal of Tissue Engineering & Regenerative Medicine, 5(6), pp.115-25.(link)

16. LQ Wan, SM Kang, G Eng, WL Grayson, XL Lu, B Huo, J Gimble, XE Guo, VC Mow, and G Vunjak-Novakovic, 2010. Geometric Control of Adult Human Stem Cell Morphology and Differentiation, Integrative Biology, 2(7-8), pp. 346-53.(link)

15. A Marsano, R Maidhof, LQ Wan, Y Wang, J Gao, N Tandon, and G Vunjak-Novakovic, 2010. Scaffold Stiffness Affects the Contractile Function of Three-Dimensional Engineered Cardiac Constructs, Biotechnology Progress, 26(5), pp.1382-90.(link)

14. XL Lu, LQ Wan, XE Guo, and VC Mow, 2010. A Linearized Formulation of Triphasic Mixture Theory for Articular Cartilage, and Its Application to Indentation Analysis, Journal of Biomechanics, 43(4), pp. 673-9.(link)

13. WL Grayson, M Fröhlich, K Yeager, S Bhumiratana, C Canizzarro, LQ Wan, E Chan, X Liu, XE Guo, and G Vunjak-Novakovic, 2010. Engineering Anatomically-Shaped Human Mandibular Bone Grafts, Proceedings of National Academy of Science, 107(8), pp. 3299-304.(link)

12. LQ Wan, XE Guo, and VC Mow, 2010. A Triphasic Orthotropic Laminate Model for Cartilage Curling Behavior: Fixed Charge Density vs. Mechanical Properties Inhomogeneity, Journal of Biomechanical Engineering, 132(2): 4504.(link)

Book Chapters

3. VC Mow, XL Lu, and LQ Wan, 2011. Rigorous Mechanics and Elegant Mathematics on the Formulation of Constitutive Laws for Complex Materials: An Example from Biomechanics, From Waves in Complex Systems to Dynamics of Generalized Continua – Tributes to YIH-HSING PAO on His 80th Birthday, K. Hutter et al eds., World Scientific Publishing Company, Singapore, pp. 285-306.

2. LQ Wan, XE Guo, and VC Mow, 2009. The Origin of Pre-Stress in Biological Tissues − A Mechano-Electrochemical Model:  A Tribute to Professor Y-C. Fung, Tributes to Yuan-Cheng Fung on His 90th Birthday: Biomechanics, from Molecules to Man, S. Chien et al eds., World Scientific Publishing Company, Singapore, pp. 21-30.

1. AJ Troken, LQ Wan, NW Marion, VC Mow, and JJ Mao, 2006. Properties of Cartilage and Meniscus, The Wiley Encyclopedia of Medical Devices and Instrumentation, J.G. Webster, eds., Wiley-Interscience, New York, NY, pp. 63-80.

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