* Dr. Wang's PhD student

$ Postdoctoral researcher in the lab

^ Undergraduate in the lab

Google Scholar Profile: Link

2021

Jing Zhao, Alan Blayney, Xiaorong Liu, Lauren Gandy, Chao Yang, Xinyue Liu, Yuanyuan Xiao, Michael S. Cosgrove, Sozanne R. Solmaz, Yingkai Zhang, David Ban, Stewart N. Loh, Jianhan Chen and Chunyu Wang (2021). EGCG Binds Intrinsically Disordered N-terminal Domain of p53 and Disrupts p53-MDM2 Interaction. Nature Communications 12: 986 (2021). Link

Xiaoxio Zhang, Xinyue Liu, Guowei Su, Miaomiao Li, Chunyu Wang (co-corresponding author) and Ding Xu (2021). pH-Dependent and Dynamic Interactions of Cystatin C with Heparan Sulfate. Communications Biology. (2021)4:198. Link

2020

Jin, W., He, X., Wu, W., Bao, Y., Wang, S., Cai, M., Zhang, W., Wang, C., Zhang, F., Linhardt, R.J. and Mao, G., (2020). Structural analysis of a glucoglucuronan derived from laminarin and the mechanisms of its anti-lung cancer activity. International Journal of Biological Macromolecules. Link

Tasissa, R. Lai, and C. Wang. (2020) Homology Initialization for Protein Structure Determination via Distance Geometry. bioRxiv, Link

Susan E. Coombs Sudeep Banjade, Ksenia Kriksunov, Nicolina Clemente, Jing Zhao, Chunyu Wang, Richard E. Gillilan, and Robert E. Oswald. Coombs SE, Banjade S, Kriksunov K, Clemente N, Zhao J, Wang C, Gillilan RE, Oswald RE (2020). In Vitro Effects of (+)MK-801 (dizocilpine) and Memantine on β-Amyloid Peptides Linked to Alzheimer's Disease. Biochemistry. 2020 Dec 8;59(48):4517-4522. Link

Kathryn M. Colelli, Jennifer M. Pusztay, Jing Zhao, Jian Xie, Chunyu Wang and Kenneth V. Mills (2020). Allosteric Influence of Extremophile Hairpin Motif Mutations on the Protein Splicing Activity of a Hyperthermophilic Intein Biochemistry (2020) Link

Jin, Weihua, Di Jiang, Wenjing Zhang, Chunyu Wang, Ke Xia, Fuming Zhang, and Robert J. Linhardt. "Interactions of fibroblast growth factors with sulfated galactofucan from Saccharina japonica." International Journal of Biological Macromolecules (2020) Link

Xinyue Liu, Yingkai Zhang, Scott Forth, Iban Ubarretxena-Belandia, Raquel Lieberman and Chunyu Wang (2020). Substrate enzyme interaction in intramembrane proteolysis. Frontiers in Molecular Neuroscience, 13: 65 Link

Jing Zhao, Zhenming Du, Chunyu Wang, Kenneth V. Mills (2020). Methods to study the structure and catalytic activity of cis-splicing inteins. In: Vila-Perelló M. (eds) Expressed Protein Ligation. Methods in Molecular Biology, vol 2133. Humana, New York, NY. Link

Carl J. Smith, Robert Stagnitta, Andrew G. Wagner, Chunyu Wang, Brian P. Callahan (2020). Diverting hedgehog protein autoprocessing with chemical activators of non-native catalysis. Biochemistry. 59 (6), 736-741. Link

Jackie Jing Zhao, Yuanyuan Xiao, Xinyue Liu, Marilia Barros, Yueming Li, Xuben Hou, Feng Xiong, Nikolaos Robakis, Jon Dordick, Yingkai Zhang, Iban Ubarretxena-Belandia and Chunyu Wang (2020). Substrate interaction inhibits intramembrane proteolysis and amyloid production. Chemical Communications. DOI: 10.1039/C9CC09170J Link

2019

Jing Zhao, Daniel A. Ciulla, Jian Xie, Andrew G. Wagner, Drew A. Castillo, Allison S. Zwarycz, Zhongqian Lin, Seth Beadle, José-Luis Giner, Zhong Li, Hongmin Li, Nilesh Banavali, Brian P. Callahan, Chunyu Wang (2019). General Base Swap Preserves Activity and Expands Substrate Tolerance in Hedgehog Autoprocessing. J. Am. Chem. Soc. Published online. DOI: 10.1021/jacs.9b08914 Link

Jing Zhao, Yanan Zhu, Xuehong Song, Yuanyuan Xiao, Guowei Su, Xinyue Liu, Zhangjie Wang, Yongmei Xu, Jian Liu, David Eliezer, Trudy F. Ramlall, Guy Lippens, James Gibson, Fuming Zhang, Robert J. Linhardt, Lianchun Wang, Chunyu Wang (2019). Rare 3‐O‐sulfation of Heparan Sulfate Enhances Tau Interaction and Cellular Uptake. Angew Chem. Int. Ed. Published online. DOI: 10.1002/anie.201913029 Link

Xiaoyu Zhang, Zihan Xu, Dina S. Moumin, Daniel A. Ciulla, Timothy S. Owen, Rebecca A. Mancusi, José-Luis Giner, Chunyu Wang, Brian P. Callahan (2019). Protein-Nucleic Acid Conjugation with Sterol Linkers Using Hedgehog Autoprocessing. Bioconjugate Chemistry. Published online. DOI: 10.1021/acs.bioconjchem.9b00550 Link

Clément Despres, Jing Di, François-Xavier Cantrelle, Zizheng Li, Isabelle Huvent, Béatrice Chambraud, Jing Zhao, Jianle Chen, Shiguo Chen, Guy Lippens, Fuming Zhang, Robert Linhardt, Chunyu Wang, Frank-Gerrit Klärner, Thomas Schrader, Isabelle Landrieu, Gal Bitan, Caroline Smet-Nocca (2019). Heparin-induced tau does not represent accurately the self-assembly and seeding of hyperphosphorylated tau and their modulation by potential inhibitors. ACS Chemical Biology. Published online. DOI: 10.1021/acschembio.9b00325 Link

Daniel Ciulla, Andrew Wagner, Liu Xinyue, Courtney Cooper, Michael Jorgensen, Chunyu Wang, Puja Goyal, Nilesh Banavali, Jose’ GinerC, Brian Callahan (2019). Sterol A-ring plasticity in hedgehog protein cholesterolysis supports a primitive substrate selectivity mechanism. Chemical Communications, 55:1829-1832. DOI: 10.1039/C8CC09729A. Link

Adam Schaffner, Xianting Li, Nina Pan, Keita Morohashi, Emmanouela Leandrou, Anna Memou, Hardy Rideout, Yacob Gomez-Llorente, Lianteng Zhi, Hui Zhang, Chen Yao, Shu G. Chen, Farinaz Afsari, Christopher J. Elliott, Nicolina Clemente, Chunyu Wang, Ming-Ming Zhou, Iban Ubarretxena-Belandia, and Zhenyu Yue. Vitamin B12 inhibits LRRK2 kinase activity and prevents deficits in LRRK2 models of PD pathogenesis. Cell Research, 29 (4): 313 DOI: 10.1038/s41422-019-0153-8. Link


2018

Nicolina Clemente, Alaa Abidine, Iban Ubarretxena-Belandia and Chunyu Wang (2018). Coupled Transmembrane Substrate Docking and Helical Unwinding in Intramembrane Proteolysis of Amyloid Precursor Protein. Scientific Reports, 8:12411. DOI:10.1038/s41598-018-30015-6 Link

David J. Rosenman, Nicolina Clemente, Muhammod Ali, Angel Garcia and Chunyu Wang (2018). High Pressure NMR Reveals Conformational Perturbations Disease-Causing Mutations in Amyloid β-Peptide. Chemical Communications, 54: 4609-4612. DOI: 10.1039/C8CC01674G. Link


2017

Christian K. Ramsoomair, Anthony E. Yakely, Laura M. Urbanski, Kevin Karanja, Zachary T. Giaccone, Nicolle M. Siegart, Julie N. Reitter, Chunyu Wang and Kenneth V. Mills (2017). Coordination of the third step of protein splicing in two cyanobacterial inteins. FEBS Letters. 591: 2147-2154. Link

Allison Zwarycz, Martin Fossat, Otar Akanyeti, Zhongqian Lin, Catherine Royer, Kenneth Mills and Chunyu Wang (2017). Structural basis of a stabilizing mutation in Mtu RecA intein revealed by high pressure NMR. Biochemistry 56: 2715-2722. DOI: 10.1021/acs.biochem.6b01264. Link

Christopher J. Minteer, Nicolle M. Siegart, Kathryn M. Colelli, Xinyue Liu, Robert J. Linhardt, Chunyu Wang, Alvin V. Gomez, Julie N. Reitter, Kenneth V. Mills (2017). Intein-promoted cyclization of aspartic acid flanking the intein leads to atypical N-terminal cleavage. Biochemistry 56: 1042-1050. Link

Jackie Zhao, David Eliezer, Guy Lippens, Pete Tessier, Robert Linhardt, Fuming Zhang and Chunyu Wang (2017). Glycan determinants of heparin/tau interaction. Biophyscial Journal 112: 921-932. Link


2016

Jian Xie*, Timothy Owen, Ke Xia, Brian Callahan and Chunyu Wang (2016). A Single Aspartate Coordinates Two Catalytic Steps in Hedgehog Autoprocessing. Journal of the American Chemical Society. 138: 10806-10809. DOI: 10.1021/jacs.6b06928 Link

David J Rosenman*, Chunyu Wang, Angel E. Garcia, (2016). Characterization of Aβ Monomers Through the Convergence of Ensemble Properties Among Simulations with Multiple Force Fields. Journal of Physical Chemistry B. 120(2): 259-277. Link


2015

Lopes DH, Attar A, Nair G, Hayden EY, Du Z$, McDaniel K, Dutt S, Bandmann H, Bravo-Rodriguez K, Mittal S., Klarner, F.-G., Wang, C., Sanchez-Garcia, E., Schrader, T. and Bitan, G. (2015). Molecular tweezers inhibit islet amyloid polypeptide assembly and toxicity by a new mechanism. ACS chemical biology. 10(6): 1555-1569. Link

Xie, J.*, Owen, T., Xia, K., Singh, A. V., Tou, E.^, Li, L., Arduini, B., Li, H., Wan, L. Q., Callahan, B., and Wang, C. (2015). Zinc Inhibits Hedgehog Autoprocessing: Linking Zinc Deficiency with Hedgehog Activation. J. Biol. Chem. 290(18): 11591-11600. Top 5 most viewed article March-April 2015 on JBC website. Link


2014

Owen, T. S., Xie, J.*, Laraway, B., Ngoje, G., Wang, C., & Callahan, B. P. (2014). “Active Site Targeting of Hedgehog Precursor Protein with Phenylarsine Oxide”. ChemBioChem 16(1):55-58. Link

K. R. Valasani, E. A. Carlson, K. P. Battaile, A. Bisson*, C. Wang, S. Lovell and S. S. Yan (2014). “High-resolution crystal structures of two crystal forms of human cyclophilin D in complex with PEG 400 molecules” Acta Cryst. F70, 717-722. Link

Wen Chen*, Eric Gamache, David Rosenman*, Jian Xie*, Maria Lopez, Yueming Li, and Chunyu Wang (2014). “Familial Alzheimer's Mutations within APPTM Increase Abeta42 Production by Enhancing the Accessibility of the Epsilon-Cleavage Site”. Nature Communications 4:3037 DOI: 10.1038/ncomms4037. Link


2013

Nicastri, Michael C., Kristina Xega, Lingyun Li, Jian Xie*, Chunyu Wang, Robert J. Linhardt, Julie N. Reitter, and Kenneth V. Mills (2013). "Internal Disulfide Bond Acts as a Switch for Intein Activity." Biochemistry 52(34): 5920-5927. Link

Jian Xie*, Zhenming Du$, Brian Callahan, Marlene Belfort and Chunyu Wang (2013). “1H, 13C and 15N NMR assignments of a Drosophila Hedgehog autoprocessing domain”. Biomolecular NMR assignments 1-3. Link

David Rosenman*, Christopher Connors*, Wen Chen*, Chunyu Wang, Angel E. Garcia, (2013). “Monomers Transiently Sample Oligomer and Fibril-like Configurations: Ensemble Characterization Using a Combined MD/NMR Approach” Journal of Molecular Biology 425(18): 3338-3359. Link

Connors, Christopher Ryan*, David Jacob Rosenman*, Dahabada HJ Lopes, Shivina Mittal, Gal Bitan, Mirco Sorci, Georges Belfort, Angel E. Garcia, and Chunyu Wang (2013). "Tranilast Binds to Aβ Monomers and Promotes Aβ Fibrillation." Biochemistry 52(23): 3995-4002. Link


2012

Yuchuan Zheng, Qin Wu, Chunyu Wang, Min-qun Xu, Yangzhong Liu (2012). “Mutual Synergistic Protein Folding in the Ssp DnaE Split Intein”. BioScience Reports 32:433-442. Link

Sharmistha Sinha, Zhenming Du$, Panchanan Maiti, Frank-Gerrit Klärner, Thomas Schrader, Chunyu Wang, Gal Bitan (2012) “Comparison of three amyloid assembly inhibitors – the sugar scyllo-inositol, the polyphenol epigallocatechin gallate, and the molecular tweezer CLR01”. ACS Chemical Neuroscience 3: 451-458. Link

Wen Chen*, Lingyun Li, Zhenming Du$, Jiajing Liu*, Julie N. Reitter, Kenneth V. Mills, Robert J. Linhardt, and Chunyu Wang (2012). “Intramolecular Disulfide Bond between Catalytic Cysteines in an Intein Precursor” Journal of the American Chemical Society. 134(5):2500-2503. Link

Chen, W.*, Gamache, E., Richardson, D., Du, Z.$ and Wang, C. (2012) “Expression, purification, and reconstitution of the transmembrane domain of the human amyloid precursor protein for NMR studies” Protein Expression and Purification 81: 11-17. Link


2011

Huiyuan Li, Zhenming Du*, Dahabada H. J. Lopes, Erica Fradinger, Chunyu Wang and Gal Bitan (2011). “C-terminal Tetrapeptide Inhibitors of Aβ42-induced Neurotoxicity Bind Preferentially at the N-terminus of Aβ42”, Journal of Medicinal Chemistry, 54(24): 8451-8460. Link

Zhenming Du$, Jiajing Liu*, Clayton D. Albracht*, Alice Hsu^, Wen Chen*, Michelle D. Marieni, Kathryn M. Colelli, Jennie E. Williams, Julie N. Reitter, Kenneth V. Mills, Chunyu Wang (2011). “Structural and Mutational Studies of a Hyperthermophilic Intein from DNA Polymerase II of Pyrococcus abyssi”, Journal of Biological Chemistry, 286: 38638-38648. With a cover illustration of Nov. 4, 2011 issue of JBC. Link

Sinha, Sharmistha; Lopes, Dahabada; Du, Zhenming; $ Pang, Eric; Shanmugam, Akila; Lomakin, Aleksey; Talbiersky, Peter; Tennstaedt, Annette; McDaniel, Kirsten; Bakshi, Reena; Kuo, Pei-Yi; Ehrmann, Michael; Benedek, George; Loo, Joseph; Klärner, Frank-Gerrit; Schrader, Thomas; Wang, Chunyu; Bitan, Gal (2011) “Lysine-specific molecular tweezers are broad-spectrum inhibitors of assembly and toxicity of amyloid proteins”, Journal of the American Chemical Society 133(42): 16958-16969. Link

Du, Z.$, Zheng, Y., Patterson, M.*, Liu, Y.$ and Wang, C. (2011) “pKa Coupling at Intein Active Site: Implications for Coordination Mechanism of Protein Splicing with a Conserved Aspartate”, Journal of the American Chemical Society 133:10275-10282. Link

Jiajing Liu*, Zhenming Du$, Roshni Naidu^, Clay Albracht*, Kenneth V. Mills and Chunyu Wang (2011). “1H, 13C, and 15N NMR assignments of intein from DNA polymerase II of Pyrococcus abyssi”. Biomolecular Assignment 5: 233-235. Link

Sgourakis, N.G., Merced-Serrano, M., Boutsidis, C., Drineas, P., Du, Z.$, Wang, C. and Garcia, A.E. (2011) “Atomic-level characterization of the ensemble of the Aβ(1-42) monomer in water using unbiased Molecular Dynamics simulations and spectral algorithms”. Journal of Molecular Biology 405: 570-583. Link


2010

Du, Z.$, Liu, Y.$, Ban, D.^, Lopez, M., Belfort, M. and Wang, C. (2010). “Backbone Dynamics and Global Effects of an Activity Enhancing Mutation in Minimized Mtu RecA Inteins”, Journal of Molecular Biology 400: 755-767. Link


2009

Hiraga K., Soga, I., Dansereau, J.T., Pereira, B., Derbyshire, V., Du, Z.$, Wang, C., Van Roey, P., Belfort, G., Belfort, M. (2009). “Selection and Structure of Hyperactive Inteins: Peripheral Changes Relayed to the Catalytic Center”, Journal of Molecular Biology 393: 1106-1117. Link

Du, Z.$, Shemella, P.T., Liu, Y., McCallum, S.A., Pereira, B., Nayak, S.K., Belfort, G., Belfort, M. and Wang, C. (2009). “Highly Conserved Histidine Plays a Dual Catalytic Role in Protein Splicing: a pKa Shift Mechanism”, Journal of the American Chemical Society 131: 11581-11589. Link

Zhang, L., Zheng, Y., Xi, Z., Luo, Z., Xu, X., Wang, C., and Liu, Y. (2009) “Metal Ions Binding to RecA Inteins from Mycobacterium tuberculosis”, Molecular BioSystems 5: 644-650. Link

Gribenko, A.V., Patel, M.M., Liu, J.*, McCallum, S.A., Wang, C., Makhatadze, G.I. (2009). “Rational Stabilization of Enzymes by Computational Redesign of Surface Charge-Charge Interactions”, Proceedings of the National Academy of Science 106: 2601-2606. Link


2008

Du, H., Guo, L., Fang, F., Chen, D., Sosunov, A., McKhann, G., Yan, Y.*, Wang, C., Zhang, H., Molkentin, J.D., Gunn-Moore, F.J., Vonsattel, J.P., Arancio, O., Chen, J.X., Yan, S.D. (2008). “Deficiency of Cyclophilin D Attenuates Mitochondrial and Neuronal Perturbation, and Ameliorates Learning Memory in Alzheimer’s Disease”, Nature Genetics 14: 1097-1105. Link

Du, Z.$, Liu, Y.$, McCallum, S., Dansereau, J., Derbyshire, V., Belfort, M., Belfort, G., Van Roey, P., Wang, C. (2008). “1H, 13C, and 15N NMR assignments of an engineered intein based on Mycobacterium tuberculosis RecA”, Biomolecular NMR Assignments 2: 111-113. Link

Yan, Y.*, McCallum, S.A., Wang, C. (2008). “M35 oxidation Causes Aβ40-like Changes in Structure and Dynamics in Aβ42”, Journal of the American Chemical Society 130: 5394-5395. Link

Shinde, A.V., Bystroff, C., Wang C., Vogelezang, M.G., Vincent, P.A., Hynes, R.O., Van DeWater, L. (2008) “Identification of the Peptide Sequences within the EIIIA (ED-A) Segment of Fibronectin that Mediate Integrin α9β1-Dependent Cellular Activities”, Journal of Biological Chemistry 283:2858-7280. Link


2007

Yan, Y.*, Liu, J.*, McCallum, S.A., Yang, D. and Wang, C. (2007) “Methyl Dynamics of the Amyloid-β peptides Aβ40 and Aβ42”, Biochemical Biophysical Research Communications 362:410-414. Link

Yin, Y.I., Bassit, B., Zhu, L., Yang, X., Wang, C. and Li, Y.-M. (2007) “γ-Secretase Substrate Concentration Modulates Aβ42/Aβ40 Ratio: Implications for Alzheimer’s Disease”, Journal of Biological Chemistry 282:23639-23644. Link

Yan, Y.* and Wang, C. (2007) “Aβ40 Protects Non-Toxic Aβ42 Monomers from Aggregation”, Journal of Molecular Biology 369:909-916. Link

Sgourakis, N., Yan, Y.*, McCallum, S., Wang, C. and Garcia, A.E. (2007) “The Alzheimer's Peptides Aβ40 and 42 Adopt Distinct Conformations in Water: A Combined MD/NMR Study”, Journal of Molecular Biology 368:1448-1457. Link

Yan, Y.*, Liu, Y.$, Sorci, M., Belfort, G., Lustbader, J.W., Yan, S.D. and Wang, C. (2007) “Surface Plasmon Resonance and Nuclear Magnetic Resonance Studies of ABAD-Aβ Interaction”, Biochemistry 46: 1724-1731. Link


2006

Yan, Y.* and Wang, C. (2006) “Aβ42 is More Rigid than Aβ40 in the C-Terminus: Implications for Aβ Aggregation and Toxicity”, Journal of Molecular Biology 364: 853-862. Link


Before RPI

Massi, F., Wang, C., Palmer, A.G. (2006). “Solution NMR and computer simulation studies of active site loop motion in triosephosphate isomerase”, Biochemistry 45: 10787-10794.

Wang, C., Karpowich, N.K., Hunt, J.F., Rance, M., Palmer, A.G. (2004) “Dynamics of ATP-Binding Cassette Contributes to Nucleotide Binding and Energy Transduction”, Journal of Molecular Biology 342: 525-537.

Grey, M.J., Wang, C., Palmer, A.G. (2003). “Disulfide Bond Isomerization in Basic Pancreatic Trypsin Inhibitor: Multi-site Chemical Exchange Quantified by CPMG Relaxation Dispersion and Chemical Shift Modeling”, Journal of the American Chemical Society 125: 14324-14335.

Wang, C., Rance, M., Palmer, A.G. (2003). “Mapping Chemical Exchange in Proteins with MW > 50 kD”, Journal of the American Chemical Society 125: 8968-8969. Selected as a “Must Read” by faculty of 1000 website (www.facultyof1000.com).

Wang, C., Hunt, J.F., Rance, M., Palmer, A.G. (2002). “1H, 15N and 13C Backbone Assignment of MJ1267, an ATP-binding Cassette”, Journal of Biomolecular NMR 24: 167-168.

Wang, C., Palmer, A.G. (2002). “Differential Multiple Quantum Relaxation Caused by Chemical Exchange outside Fast Exchange Limit”, Journal of Biomolecular NMR 24: 263-268.

Wang, C., Grey, M.J., Palmer, A.G. (2001). “New CPMG Sequences with Enhanced Sensitivity to Chemical Exchange”, Journal of Biomolecular NMR 21: 361-366.

Pawley, N., Wang, C., Koide, S., Nicholson, L.K. (2001). “An Improved Method for Distinguishing Anisotropic Tumbling and Chemical Exchange in Analysis of 15N Relaxation Parameters”, Journal of Biomolecular NMR 20: 149-165.

Wang, C., Pawley, N., Nicholson, L. (2001). “The Role of Backbone Motions in Ligand Binding to the c-Src SH3 Domain”, Journal of Molecular Biology 313: 873-887.

Wang, C., Xi, J., Begley, T. P., Nicholson, L.K. (2001), “Solution Structure of This and Implications for the Evolutionary Roots of Ubiquitin”, Nature Structural Biology 8: 47-51. Selected as Editor’s Choice in Jan. 19, 2001 issue of Science.

Cordier, F., Wang, C., Grzesiek, S., Nicholson, L.K. (2000), “Ligand-Induced Strain in Hydrogen Bonds of the c-Src SH3 Domain Detected by NMR”, Journal of Molecular Biology 304: 497-505. With an accompanying cover illustration and highlighted on the Academic Press website.