Chunyu Wang, MD, PhD

Chunyu Wang, professor of Biological Sciences, and Chemistry and Chemical Biology at RPI, is an expert in NMR (nuclear magnetic resonance) structural biology and in structural mechanisms of Alzheimer’s disease and cancer. He obtained his MD in 1996 from Peking Union Medical College (PUMC). He was then trained in structural biology at Cornell University under the guidance of Linda Nicholson, earning a PhD in Molecular Biology and Genetics in 2000. He carried out postdoctoral work at Columbia University in Art Palmer’s group. After establishing his own research group at RPI in 2005, he developed a strong research program in structural mechanisms in protein autoprocessing and Alzheimer’s disease. Recently, his group is venturing into new and exciting areas such as drug discovery and biological sulfation. He has been awarded multiple grants from NIH and several grants for Alzheimer’s research, from Alzheimer’s Association, Warren Alpert Foundation, New York State and American Health Assistance Foundation (Now BrightFocus foundation).

Personal interests: Bridge, Tennis

Research Associates

Nabin

Postdoctoral Associate

Nabin's expertise and research interest are in molecular biophysics of proteins involved in Alzheimer’s and cancer, as well as physical properties of lipid membranes and protein-lipid interactions. He has broad expertise in spectroscopic techniques such as fluorescence, circular dichroism, Fourier transform infrared spectroscopy and solid-state NMR. Nabin received his BS in Physics (Physics, Chemistry, Math) from Tribhuvan University, Nepal in 2010. He moved to University of Texas, Brownsville, USA in 2012 where he got his MS in Physics (Biophysics). In 2014, Nabin joined University of Central Florida (USF), Orlando, USA and received his PhD in Physics in 2019. During his PhD, he worked on the structure-function relation of the membrane pore formed by amyloid beta peptide using spectroscopic techniques including solid state NMR. He then worked as a joint-postdoctoral researcher (2019-2020) between USF and University of California, Irvine to probe the self-assembly of Reflectin (Ref2Cx4) protein that comes from the light organs of cephalopods. In 2020, Nabin joined Dr. Wang's lab here in RPI to work on single molecule kinetic studies of the mechanism of gamma-secretase and familial Alzheimer's Disease. His projects also include biophysical characterizations of tau and p53.

Nabin Kandel

James Gibson

Research Associate

James earned his BS in chemistry from Harvey Mudd College in 1995. He earned his PhD in chemistry from Penn State in 2001, where he studied solid-state NMR under Professor Karl T. Mueller. While at Penn State, he primarily worked on solid-state NMR method development and the application of solid-state NMR to glasses. James was a postdoc at the University of Washington from 2001 to 2005, where he had his first foray into biological sciences under the direction of Professors Patrick S. Stayton (bioengineering) and Gary P. Drobny (chemistry). While there, he studied the interactions and dynamics of the binding of salivary peptides to hydroxyapatite, the main mineral component of teeth using solid-state NMR. James ventured into solution-state NMR of proteins under the direction of Professor James G. Kempf in the chemistry department at RPI in 2006 and 2007, primarily working to understand how different CPMG-type sequences worked together. After that, he spent 10 years in industry performing solution-state NMR on silicone materials and their precursors. In 2018, James came back to RPI to work in Dr. Wang's research group. He studies the interactions of proteins and their binding partners with high resolution NMR spectroscopy. He is also responsible for adapting pulse sequences from other laboratories to our laboratory for use.

James Gibson

Graduate Students

Bailey Eden

Graduate

She received her BS in chemistry from the University of Central Arkansas and she came to RPI in September 2018 to get her PhD in chemistry. Projects that Bailey is working on include drug screening for Alzheimer’s Disease, using NMR to characterize drug/protein interactions and structure function relationships.

Bailey Eden

Adrianne Bunn

Graduate

Adrianne is from Minneapolis, MN, and started her education at Minneapolis Community and Technical College earning an A.A. in Liberal Arts. She graduated with a B.S. in Chemistry with an emphasis on Biochemistry from the University of Wisconsin-River Falls. She came to RPI in the fall of 2018 to pursue her Ph.D. in Biochemistry and Biophysics. Her focus is on studying protein-protein and protein-glycan interactions in cancer, Alzheimer's disease, and Parkinson's disease, using NMR and SPR. In her free time, Adrianne enjoys bicycling, birdwatching, and canoeing.

Adrianne Bunn

Dylan Mah

Graduate

Dylan Mah is a first-year doctoral student in biology who joined the Wang Lab in the Spring of 2019. After graduating from SUNY Binghamton University in 2015 with a B.S. in Cell and Molecular Biology. He spent a year working in a clinical laboratory prior to coming to RPI in the Fall of 2018. His area of research interest is the molecular biology of aging and age-related diseases, with a focus on neurodegenerative diseases such as Alzheimer’s.

Dylan Mah

Lauren Gandy

Graduate

Lauren obtained a BS in Forensic Science - Biochemsitry and BA in French at the University of Central Florida in 2017. Her previous technical experience includes developing field techniques for gunshot residue analysis, comparing different DNA collection and storage devices for forensic profiling purposes, and analyzing volatile organic compounds using thermal desorption, sorptive extraction, and gas chromatography. Lauren joined the Rensselaer PhD Chemistry program in Fall 2017, and aims to work for a state forensic laboratory after obtaining her doctorate.

Lauren Gandy

Shannon Faris

Graduate

Shannon graduated from the University of New Haven with a B.S. in Chemistry and a B.S. in Forensic Science. She joined RPI in Fall of 2019 to work towards a Ph.D. in chemistry. Shannon’s current research focuses primarily in pharmacology, drug discovery and potential inhibiters of neuro-degenerative disease, with an emphasis on Alzheimer’s.

Shannon Faris

Undergraduate Students

Martina Zhuang

Undergraduate

She studies Biomedical Engineering in the class of 2020. She’s been in the lab since Fall 2016 and she helps fellow lab members in their projects.

Martina Zhuang

Yuechen Liu

Undergraduate

She is in the Class of 2020 and majors in Biochemistry and Biophysics (BCBP). She has a strong interest in research in proteins and genetics and joined Dr. Wang's research lab in Spring, 2019.

Yuechen Liu

Yanhao Li

Undergraduate

He majors in Biochemistry and Biophysics (BCBP) in the class of 2020. He is interested in biostatistics and joined the C.Wang Research Lab in the Spring of 2019.

Yanhao Li

Tara Azam

Undergraduate

Tara is from New Smyrna Beach, Florida and studies Biochemistry/Biophysics in the class of 2021. She has been working with graduate student Adrianne Bunn since Fall 2019. Her focus is on Alzheimer's disease and Parkinson's disease protein interactions using NMR, SPR, and other biophysical techniques. In her free time, Tara loves swimming, eating sushi, and reading lots of papers!

Tara Azam




Current Rotation Students

Nathan Smith

Nathan Smith

Rotation Student

Nathan is from Bradford Pennsylvania. He graduated from Mount Aloysius College in the spring of 2020 with a bachelors degree in Biology with specializations in Molecular Biotechnology and Pre-Health as well as minors in Scientific Communications and Vocal Performance. He began his first year as a PhD student in the BCBP program in the fall. He will characterize the conformational dynamics and interactions of tau.





Anqesha Murray

Anqesha Murray

Rotation Student

Anqesha is from Rochester, New York, and received her associate’s degree in Liberal Arts and Biology from Monroe Community College in 2014. She completed her bachelor’s degree in Biological Sciences with a concentration in Microbiology and Immunology and a minor in American Sign Language and Dance at the University of Rochester. She then attended Brown University as an NIH Post-Baccalaureate Research Education Program (PREP) Scholar in the Department of Molecular Microbiology and Immunology. Anqesha came to Rensselaer Polytechnic Institute (RPI) in the fall of 2020 to pursue her PhD in Biology. She projects focus on alpha-synuclein.

See Past Members and Collaborators