1. 1.Tiller, K.E., Li, L., Kumar, S., Garde, S., Tessier, P.M., “Arginine mutations in antibody complementarity-determining regions display context-dependent affinity/specificity trade-offs”, in review, submitted Mar 7 (2017).

  1. 2.Julian, M.C., Li, L., Garde, S., Wilen, R., Tessier, P.M., “Efficient affinity maturation of antibody variable domains requires co-selection of compensatory mutations to maintain thermodynamic stability”, Sci Rep, 7, 45259 (2017). [link]

  1. 3.Zhao, J., Huvent, I., Lippens, G., Eliezer, D., Zhang, A., Li, Q., Tessier, P.M., Linhardt, R.J., Zhang, F., Wang, C., “Glycan determinants of heparin-tau interaction," Biophys J, 112, 921 (2017). [link]

  1. 4.Nilvebrant, J., Tessier, P.M., Sidhu, S.S., “Engineered autonomous human variable domains”, Curr Pharm Des, 22, 1 (2016). [link]

  1. 5.Geng, S.B., Wu, J., Schultz, J.S., Dickinson, C.D., Seminar, C.R., Alam, M.E., Tessier, P.M., “Facile preparation of stable antibody-gold conjugates and application to affinity-capture self-interaction nanoparticle spectroscopy”, Bioconjug Chem, 27, 2287 (2016). [link]

  2. 6.Geng, S.B., Wittekind, M., Vigil, A. Tessier, P.M., “Measurements of monoclonal antibody self-association are correlated with complex biophysical properties”, Mol Pharm, 13, 1636 (2016). [link]

  1. 7.Osborne, D.M., Fitzgerald, D.P., O'Leary, K.E., Anderson, B.M., Lee, C.C., Tessier, P.M., McNay, E.C., “Intrahippocampal administration of a domain antibody that binds aggregated amyloid-β reverses cognitive deficits produced by diet-induced obesity”, Biochim Biophys Acta, 1860, 1291 (2016). [link]

  1. 8.Lee, C.C., Julian, M.C., Tiller, K.E., Meng, F., DuConge, S.E., Akter, R., Raleigh, D.P., Tessier, P.M., “Design and optimization of anti-amyloid domain antibodies specific for Aβ and IAPP”, J Biol Chem, 291, 2858 (2016). [link]

  1. 9.Tiller, K.E., Tessier, P.M., “Advances in antibody design”, Ann Rev Biomed Eng, 17, 191 (2015). [link]

  1. 10.Julian, M.C., Lee, C.L, Tiller, K.E., Rabia, L.A., Day, E.K., Schick III, A.J., Peter M. Tessier, “Co-evolution of affinity and stability of grafted amyloid-motif domain antibodies”, Protein Eng Des Sel, 28, 339 (2015). [link]

  1. 11.Wu, J, Schultz, J.S., Weldon, C.L., Sule, S.V., Chai, Q., Dickinson, C.D., Tessier, P.M., “Discovery of highly soluble antibodies prior to purification using affinity-capture self-interaction nanoparticle spectroscopy”, Protein Eng Des Sel, 28, 493 (2015). [link]

  1. 12.McBride, S.A., Tilger, C.F., Sanford, S.P., Tessier, P.M., Hirsa, A.H., “Comparison of human and bovine insulin amyloidogenesis under uniform shear”, J Phys Chem B, 119, 10426 (2015). [link]

  1. 13.Estep, P., Caffry, I., Yu, Y., Sun, T., Cao, Y., Leanaugh, H., Jain, T., Vásquez, M., Tessier, P.M., Xu, Y., “An alternative assay to hydrophobic interaction chromatography for high-throughput characterization of monoclonal antibodies”, mAbs, 4, 553 (2015). [link]

  1. 14.Li, X., Geng, S.B., Chiu, M.L., Saro, D., Tessier, P.M., “High-throughput assay for measuring monoclonal antibody self-association and aggregation in serum”, Bioconjug Chem, 26, 520  (2015). [link]

  1. 15.Geng, S.B., Cheung, J.K., Narasimhan, C., Shameem, M., Tessier, P.M., “Improving monoclonal antibody selection and engineering using measurements of colloidal protein interactions”, J Pharm Sci, 103, 3356 (2014). [link]

  1. 16.Jayaraman, J., Wu, J., Brunelle, M.C., Cruz, A.M., Goldberg, D.S., Lobo, B., Shah, A., Tessier, P.M., “Plasmonic measurements of monoclonal antibody self-association using self-interaction nanoparticle spectroscopy”, Biotech Bioeng, 111, 1513 (2014). [link]

  1. 17.Tessier, P.M., Wu, J., Dickinson, C.G., “Emerging methods for identifying monoclonal antibodies with low propensity to self-associate during the early discovery process”, Expert Opin Drug Deliv, 11, 461 (2014). [link]

  1. 18.Perchiacca, J.M., Lee, C.C, Tessier, P.M., “Optimal charged mutations in the complementarity-determining regions that prevent domain antibody aggregation are dependent on the antibody scaffold”, Protein Eng Des Sel, 27, 29 (2014). [link]

  1. 19.Liu, Y., Caffry, I., Wu, J., Geng, S.B., Jain, T., Sun, T., Reid, F., Cao, Y., Estep, P., Yu, Y., Vásquez, M., Tessier, P.M., Xu, Y., “High-throughput screening for developability during early-stage antibody discovery using self-interaction nanoparticle spectroscopy”, mAbs, 6, 483 (2013). [link]

  1. 20.Li, X., Zhang, X., Ladiwala, A.R.A, Du, D., Yadav, J.K., Tessier, P.M., Wright, P.E., Kelly, J.W., Buxbaum, J.N., “Mechanisms of transthyretin inhibition of Aβ aggregation in vitro”, J Neurosci, 33, 19423 (2013). [link]

  1. 21.Andersson, E.K., Bengtsson, C., Evans, M.L., Chorell, E., Sellstedt, M., Lindgren, A.E.G., Hufnagel, D.A., Bhattacharya, M., Tessier, P.M., Wittung-Stafshede, P., Almqvist, F., Chapman, M.R., “Modulation of curli assembly and pellicle biofilm formation by chemical and protein chaperones”, Chem Biol, 20, 1245 (2013). [link]

  1. 22.Lee, C., Perchiacca, J.M., Tessier, P.M., “Toward aggregation-resistant antibodies by design”, Trends Biotechnol, 31, 612  (2013). [link]

  1. 23.Tiller, K.E., Tessier, P.M., “Lifting the veil on amyloid drug design”, eLife, 2, e00857 (2013). [link]

  1. 24.Sule, S.V., Dickinson, C.G., Lu, J., Chow, C.-K., Tessier, P.M., “Rapid analysis of antibody self-association in complex mixtures using immunogold conjugates”, Mol Pharm, 10, 1322 (2013). [link]

  1. 25.Ladiwala, A.R.A., Bhattacharya, M., Perchiacca, J.M., Cao, P., Raleigh, D.P., Abedini, A., Schmidt, A.M., Varkey, J., Langen, R., Tessier, P.M., "Rational design of potent domain antibody inhibitors of amyloid fibril assembly", P Natl Acad Sci U S A, 109, 19965 (2012). [link]

  1. 26.Perchiacca, J.M., Ladiwala, A.R.A., Bhattacharya, M., Tessier, P.M., "Aggregation-resistant domain antibodies engineered with charged mutations near the edges of the complementarity-determining regions", Protein Eng Des Sel, 12, 591 (2012). [link]

  1. 27.Ladiwala, A.R, Litt, J., Kane, R.S., Aucoin, D.S., Smith, S.O., Ranjan, S, Davis, J., Van Nostrand, W.E., Tessier, P.M., "Conformational differences between two amyloid β oligomers of similar size and dissimilar toxicity", J Biol Chem, 287, 24765 (2012). [link]

  1. 28. Ladiwala, A.R, Perchiacca, J.M., Fishman, Z.S., Bhattacharya, M., Hickey, A.M., Domigan, B.G., Dordick, J.S., Tessier, P.M., "Polyphenolic disaccharides endow proteins with unusual resistance to aggregation", Biotech Bioeng, 109, 1869 (2012). [link]

  1. 29.Perchiacca, J.M., Tessier, P.M., "Engineering aggregation-resistant antibodies", Ann Rev Chem Biomol Eng, 3, 263 (2012). [link]

  1. 30.Sule, S.V., Cheung, J., Antochshuk, V., Bhalla, A., Narasimhan, C., Blaisdell, S., Shameem, M., Tessier, P.M., "Solution pH that minimizes self-association of three monoclonal antibodies is strongly dependent on ionic strength", Mol Pharm, 9, 744 (2012). [link]

  1. 31.Perchiacca, J.P., Ladiwala, A.R.A, Bhattacharya, M.B., Tessier, P.M., "Structure-based design of conformation- and sequence-specific antibodies against amyloid β", P Natl Acad Sci U S A, 109, 84 (2012). [link]

  1. 32.Posada, D., Tessier, P.M., Hirsa, A.H., "Removal versus fragmentation of amyloid-forming precursors via membrane filtration", Biotech Bioeng, 109, 840 (2012). [link]

  1. 33.Sule, S.V., Sukumar, M., Weiss, W.F., Marcelino-Cruz, A.M., Sample, T., Tessier, P.M., "High-throughput analysis of concentration-dependent antibody self-association", Biophys J, 101, 1749 (2011). [link]

  1. 34.Marcelino-Cruz, A.M., Bhattacharya, M., Anselmo, A., Tessier, P.M., "Site-specific structural analysis of a yeast prion strain with species-specific seeding activity", Prion, 5, 208 (2011). [link]

  1. 35.Ladiwala, A.R, Mora-Pale, M., Lin, J.C., Bale, S.S., Fishman, Z.S., Dordick, J.S., Tessier, P.M., "Polyphenolic glycosides and aglycones utilize opposing pathways to selectively remodel and inactivate toxic oligomers of amyloid β", ChemBioChem, 12, 1749 (2011). [link]

  1. 36.Perchiacca, J.M., Bhattacharya, M., Tessier, P.M., "Mutational analysis of domain antibodies reveals aggregation hotspots within and near the complementarity determining regions", Proteins, 79, 2637 (2011). [link]

  1. 37.Ladiwala, A.R., Dordick J.S., Tessier, P.M., “Aromatic small molecules remodel toxic soluble oligomers of amyloid ß through three independent pathways”, J Biol Chem, 286, 3209 (2011). [link]

  1. 38.Ladiwala, A.R., Lin, J.C., Bale, S.S., Marcelino-Cruz, A.M., Bhattacharya, M., Dordick, J.S., Tessier, P.M., “Resveratrol selectively remodels soluble oligomers and fibrils of amyloid Aß into off-pathway conformers”, J Biol Chem, 285, 24228 (2010). [link]

  1. 39.Tessier, P.M., Lindquist, S.L., "Unraveling molecular mechanisms and structures of self-perpetuating prions", in Protein Misfolding Diseases: Current and Emerging Principles and Therapies, John Wiley & Sons. Dobson, C.M., Kelly, J.W. and Ramirez-Alvarado, M. Eds., (2010).

  1. 40.Tessier, P.M., Lindquist, S.L, “Unraveling molecular interactions and structures of self-perpetuating prions and amyloids”, Nat Struct Mol Biol, 16, 598 (2009). [link]

  1. 41.Bengali, A.N., Tessier, P.M., "Biospecific immobilization of proteins for rapid analysis of weak protein interactions using self-interaction nanoparticle spectroscopy", Biotechnol Bioeng,104, 240 (2009). [link]

  1. 42.Tessier, P.M., Jinkoji, J., Cheng, Y.-C., Prentice, J.L., Lenhoff, A.M., “Self-interaction nanoparticle spectroscopy: A nanoparticle-based protein interaction assay,” J Am Chem Soc, 130, 3106 (2008). [link]

  1. 43.Tessier P.M., Lindquist S., “Prion recognition elements govern nucleation, strain specificity and species barriers,” Nature, 447, 557 (2007). [link] See accompanying commentaries in Nature, 447, 541(2007) [link], Nat Methods, 4, 538 (2007) [link] & J Cell Biol, 177, 747 (2007) [link].

  1. 44.Tessier, P.M., Sandler, S.I., Lenhoff, A.M., “Direct measurement of protein osmotic second virial cross coefficients by cross-interaction chromatography,” Protein Sci, 13, 1379 (2004). [link]

  1. 45.Tessier, P.M., Johnson, H.R., Pazhianur, R., Berger, B.W., Prentice, J.L., Bahnson, B.J., Sandler, S.I., Lenhoff, A.M., “Predictive crystallization of ribonuclease A via rapid screening of osmotic second virial coefficients,” Proteins, 50, 303 (2003). [link]

  1. 46.Tessier, P.M., Lenhoff, A.M., “Measurement of protein self-association as a guide to crystallization,” Curr Opin Biotechnol,14, 512 (2003). [link]

  1. 47.Tessier, P.M., Verruto, V.J., Sandler, S.I., Lenhoff, A.M., “Correlation of diafiltration sieving behavior of lysozyme-BSA mixtures with osmotic second virial cross coefficients,” Biotechol Bioeng, 87, 303 (2003). [link]

  1. 48.Tessier, P.M., Lenhoff, A.M., Sandler, S.I., “Rapid measurement of protein osmotic second virial coefficients by self-interaction chromatography,” Biophys J, 82, 1620 (2002). [link]

  1. 49.Tessier, P.M., Vandrey, S.D., Berger, B.W., Sandler, S.I., Lenhoff, A.M., “Self-interaction chromatography: A novel screening method for rational protein crystallization,” Acta Cryst D, 58, 1531 (2002). [link]

  1. 50.Tessier P.M., Christesen S.D., Ong K.K., Clemente E.M., Lenhoff A.M., Kaler E.W., Velev O.D., “On-line spectroscopic characterization of sodium cyanide with nanostructured gold SERS substrates,” Appl Spectrosc, 56, 1524 (2002). [link]

  1. 51.Tessier P.M., Velev O.D., Kalambur A.T., Lenhoff A.M., Rabolt J.F., Kaler E.W., “Structured metallic films for optical and spectroscopic applications via colloidal crystal templating,” Adv Mater, 13, 396 (2001). [link]

  1. 52.Tessier P.M., Velev O.D., Kalambur A.T., Rabolt J.F., Lenhoff A.M., Kaler E.W., “Assembly of gold nanostructured films templated by colloidal crystals and use in surface-enhanced Raman spectroscopy,” J Am Chem Soc, 122, 9554 (2000). [link]

  1. 53.Velev O.D., Tessier P.M., Lenhoff A.M., Kaler E.W., “A class of porous metallic nanostructures,” Nature, 401, 548 (1999). [link]






Lab members

Open positions

Lab news:

Lab discovers how antibodies overcome key affinity/stability trade-offs during affinity maturation (Scientific Reports, Mar 2017) [link]

Tessier co-chairs the 7th International Conference on Biomolecular Engineering (Jan 2017) [link]

Tessier presents the keynote lecture at RPI’s Trustee Celebration of Faculty Achievement (Dec 2016) [link]

Lab receives NSF grant to develop new antibody design and evolution methods (Aug 2016) [link]

Lab discovers a novel method for preparing stable antibody-gold conjugates and demonstrates their use in high-throughput screening applications (Aug 2016) [link]

Tessier promoted to Full Professor (Jul 2016) [link]

Tessier awarded the 2016 Biochemical Engineering Journal Young Investigator Award (Jun 2016) [link]

Lab reports a high-throughput method for assessing complex biophysical properties of therapeutic antibodies (Apr 2016) [link]

Lab discovers (in collaboration with the McNay lab at UAlbany) that their designed Alzheimer’s antibodies improve hippocampal signaling in rat models of diet-induced obesity (Mar 2016) [link]

Lab reports improved methods for designing anti-amyloid antibodies (Nov 2015) [link]

Lab reports a novel method for co-evolving antibody affinity and stability (Sept 2015) [link]

Lab discovers that highly soluble monoclonal antibodies can be identified prior to purification using a nanoparticle-based assay (Sept 2015) [link]

Lab publishes a review on Advances in Antibody Design in Annual Reviews in Biomedical Engineering

(Aug 2015) [link]

Tessier selected to participate in the 2015 U.S. National Academy of Engineering’s Frontiers of Engineering Symposium

(July 2015) [link]

Lab reports a nanoparticle screening method for detecting antibody aggregation in serum (Feb 2015) [link]

Tessier awarded the 2015 Biochemical Technology Young Investigator Award from the American Chemical Society (Dec 2014) [link]

Tessier named one of 30 young scientists under the age of 40 to be honored at the World Economic Forum in Tianjin, China (Sept 2014) [WEF link] [RPI link]

Tessier appointed the Richard Baruch M.D. Career Development (Endowed) Chair in Engineering (June 2014) [link]

Tessier named Review Editor for Frontiers in Molecular Biosciences (May 2014)

Tessier lab members Lilia Rabia (PhD student) and Evan Day (undergraduate student) awarded NSF Graduate Fellowships (April 2014)

Tessier awarded a Humboldt fellowship to support his research at the Max Planck Institute for Biochemistry (Mar 2014)

Lab discovers unique solubiliizing activities of positively and negatively charged mutations within the binding loops of single-domain antibodies (Jan 2014) [link]

Joe Perchiacca and Shantanu Sule (graduate students in the Tessier lab) win the 2013 Peterson Awards from the American Chemical Society (Division of Biochemical Technology) for best oral (Joe) and poster (Shantanu) presentations (Dec 2013)

Lab awarded NIH R01 to develop methods for designing antibody fragments specific for amyloid proteins (Dec 2013)

Lab publishes a review article on aggregation-resistant antibodies in Trends in Biotechnology (Aug 2013) [link]

Lab publishes an insight article on amyloid toxicity inhibitors in eLife (July 2013) [link]

Tessier named
Assistant Editor of the Journal of Biological Chemistry (April 2013)

Mark Julian (graduate student in Tessier lab) awarded an NSF Graduate Fellowship  (March 2013)

Tessier wins Rensselaer's School of Engineering Teaching Excellence Award (March 2013)

Lab reports a high-throughput method for assaying antibody stability during antibody selection in Molecular Pharmaceutics (Feb 2013) [link]

Tessier granted early tenure and will be promoted to Associate Professor in July 2013 (Dec 2012)

Lab reports a new method for designing potent antibody inhibitors of amyloid formation in PNAS (Oct 2012) [link to PNAS] [link to news story]

Lab awarded grant from NY State to develop Alzheimer’s antibodies  (Sept 2012) [link]

Kathryn Tiller (graduate student in Tessier lab) awarded an NSF Graduate Fellowship  (Sept 2012)

Lab awarded an NSF grant to develop methods for designing conformation-specific antibodies (Sept 2012) [link]

Lab reports a novel approach for engineering aggregation-resistant domain antibodies in Protein Engineering, Design & Selection (June 2012) [link]

Tessier presents the Allan P. Colburn Memorial Lecture at the University of Delaware (May 2012) [link]

Lab discovers key structural features of toxic oligomers of the Alzheimer's beta-amyloid peptide (April 2012) [link]

Tessier wins Rensselaer's Early Career Award (April 2012) [link]

Tessier wins Rensselaer's School of Engineering Research Excellence Award (April 2012) [link]

Ali Reza Ladiwala (graduate student in Tessier lab) wins Rensselaer's Karen and Lester Gerhardt Prize in Science and Engineering (April 2012)

Lab discovers that polyphenolic disaccharides are unusually effective at preventing protein aggregation (February 2012) [link]

Lab reports a motif-grafting strategy for designing conformation-specific antibodies against beta-amyloid oligomers and fibrils in PNAS (October 2011) [link to PNAS] [link to news story]

Lab reports a high-throughput, nanoparticle-based screening method for measuring monoclonal antibody self-association in Biophysical Journal (August 2011) [link]

Lab identifies structural mechanisms used by infectious prions to cross species barriers (August 2011) [link]

Lab discovers that aromatic compounds conjugated with sugars potently disaggregate toxic oligomers of beta-amyloid associated with Alzheimer's disease (June 2011) [link]

Lab identifies novel mutations that prevent antibody aggregation (May 2011) [link]

Lab awarded grant from the American Health Assistance Foundation to investigate structural differences between toxic and non-toxic oligomers of beta-amyloid associated with Alzheimer's disease (March 2011) [link]

Genetic Engineering News featured high-throughput protein self-interaction research in Tessier lab (February 2011) [link]

Lab reports three pathways used by aromatic small molecules to selectively remodel toxic soluble oligomers and fibrils of beta-amyloid in the Journal of Biological Chemistry (November 2010) [link]

Tessier wins Pew Scholars Award in Biomedical Sciences (June 2010) [link]

Lab reports that resveratrol selectively remodels toxic soluble oligomers and fibrils of beta-amyloid in the Journal of Biological Chemistry (May 2010) [link]

Tessier wins NSF CAREER Award (March 2010) [link]

Tessier & Lindquist publish a review in Nature Structural & Molecular Biology on prion structure, conformational variants and species barriers (June 2009) [link]

Lab publishes new approach for measuring weak protein interactions in Biotechnology & Bioengineering (June 2009) [link]

Lab awarded NIH grant to study the structural basis of species-specific infectivities of prion strain variants (May 2009)

Tessier awarded Alzheimer’s Association New Investigator Research Grant (July 2008) [link]

Lab publishes JACS paper on self-interaction nanoparticle spectroscopy (Feb 2008) [link]