1. 1.Osborne, D.M., Fitzgerald, D.P., O’Leary, K.E., Anderson, B.M., Lee, C.C., Tessier, P.M., McNay, E.C., “Intrahippocampal administration of a domain antibody that binds aggregated amyloid-beta reverses cognitive deficits produced by a high-fat diet”, in review (2015).

  1. 2.Li, X., Geng, S.B., Chiu, M.L., Saro, D., Tessier, P.M., “A high-throughput assay for measuring monoclonal antibody self-association and aggregation in serum”, Bioconjug Chem, accepted Feb 25 (2015). [link]

  1. 3.Estep, P., Caffry, I., Yu, Y., Sun, T., Cao, Y., Leanaugh, H., Jain, T., Vásquez, M., Tessier, P.M., Xu, Y., “An alternative assay to hydrophobic interaction chromatography for high-throughput characterization of monoclonal antibodies”, mAbs, accepted Jan 26  (2015).

  1. 4.Tiller, K.E., Tessier, P.M., “Advances in antibody design”, Ann Rev Biomed Eng, accepted Jan 26 (2015). [link]

  1. 5.Geng, S.B., Cheung, J.K., Narasimhan, C., Shameem, M., Tessier, P.M., “Improving monoclonal antibody selection and engineering using measurements of colloidal protein interactions”, J Pharm. Sci., 103, 3356 (2014). [link]

  1. 6.Jayaraman, J., Wu, J., Brunelle, M.C., Cruz, A.M., Goldberg, D.S., Lobo, B., Shah, A., Tessier, P.M., “Plasmonic measurements of monoclonal antibody self-association using self-interaction nanoparticle spectroscopy”, Biotech. Bioeng., 111, 1513 (2014). [link]

  1. 7.Tessier, P.M., Wu, J., Dickinson, C.G., “Emerging methods for identifying monoclonal antibodies with low propensity to self-associate during the early discovery process”, Expert Opin. Drug Deliv., 11, 461 (2014). [link]

  1. 8.Perchiacca, J.M., Lee, C.C, Tessier, P.M., “Optimal charged mutations in the complementarity-determining regions that prevent domain antibody aggregation are dependent on the antibody scaffold”, Protein Eng. Des. Sel., 27, 29 (2014). [link]

  1. 9.Liu, Y., Caffry, I., Wu, J., Geng, S.B., Jain, T., Sun, T., Reid, F., Cao, Y., Estep, P., Yu, Y., Vásquez, M., Tessier, P.M., Xu, Y., “High-throughput screening for developability during early-stage antibody discovery using self-interaction nanoparticle spectroscopy”, mAbs, 6, 483 (2013). [link]

  1. 10.Li, X., Zhang, X., Ladiwala, A.R.A, Du, D., Yadav, J.K., Tessier, P.M., Wright, P.E., Kelly, J.W., Buxbaum, J.N., “Mechanisms of transthyretin inhibition of Aβ aggregation in vitro”, J. Neurosci., 33, 19423 (2013). [link]

  1. 11.Andersson, E.K., Bengtsson, C., Evans, M.L., Chorell, E., Sellstedt, M., Lindgren, A.E.G., Hufnagel, D.A., Bhattacharya, M., Tessier, P.M., Wittung-Stafshede, P., Almqvist, F., Chapman, M.R., “Modulation of curli assembly and pellicle biofilm formation by chemical and protein chaperones”, Chem. Biol., 20, 1245 (2013). [link]

  1. 12.Lee, C., Perchiacca, J.M., Tessier, P.M., “Toward aggregation-resistant antibodies by design”, Trends Biotechnol., 31, 612  (2013). [link]

  1. 13.Tiller, K.E., Tessier, P.M., “Lifting the veil on amyloid drug design”, eLife, 2, e00857 (2013). [link]

  1. 14.Sule, S.V., Dickinson, C.G., Lu, J., Chow, C.-K., Tessier, P.M., “Rapid analysis of antibody self-association in complex mixtures using immunogold conjugates”, Mol. Pharm., 10, 1322 (2013). [link]

  1. 15.Ladiwala, A.R.A., Bhattacharya, M., Perchiacca, J.M., Cao, P., Raleigh, D.P., Abedini, A., Schmidt, A.M., Varkey, J., Langen, R., Tessier, P.M., "Rational design of potent domain antibody inhibitors of amyloid fibril assembly", P. Natl. Acad. Sci. U. S. A., 109, 19965 (2012). [link]

  1. 16.Perchiacca, J.M., Ladiwala, A.R.A., Bhattacharya, M., Tessier, P.M., "Aggregation-resistant domain antibodies engineered with charged mutations near the edges of the complementarity-determining regions", Protein Eng. Des. Sel., 12, 591 (2012). [link]

  1. 17.Ladiwala, A.R, Litt, J., Kane, R.S., Aucoin, D.S., Smith, S.O., Ranjan, S, Davis, J., Van Nostrand, W.E., Tessier, P.M., "Conformational differences between two amyloid β oligomers of similar size and dissimilar toxicity", J. Biol. Chem., 287, 24765  (2012). [link]

  1. 18. Ladiwala, A.R, Perchiacca, J.M., Fishman, Z.S., Bhattacharya, M., Hickey, A.M., Domigan, B.G., Dordick, J.S., Tessier, P.M., "Polyphenolic disaccharides endow proteins with unusual resistance to aggregation", Biotech. Bioeng., 109, 1869 (2012). [link]

  1. 19.Perchiacca, J.M., Tessier, P.M., "Engineering aggregation-resistant antibodies", Ann. Rev. Chem. Biomol. Eng., 3, 263 (2012). [link]

  1. 20.Sule, S.V., Cheung, J., Antochshuk, V., Bhalla, A., Narasimhan, C., Blaisdell, S., Shameem, M., Tessier, P.M., "Solution pH that minimizes self-association of three monoclonal antibodies is strongly dependent on ionic strength", Mol. Pharm., 9, 744 (2012). [link]

  1. 21.Perchiacca, J.P., Ladiwala, A.R.A, Bhattacharya, M.B., Tessier, P.M., "Structure-based design of conformation- and sequence-specific antibodies against amyloid β", P. Natl. Acad. Sci. U. S. A., 109, 84 (2012). [link]

  1. 22.Posada, D., Tessier, P.M., Hirsa, A.H., "Removal versus fragmentation of amyloid-forming precursors via membrane filtration", Biotech. Bioeng., 109, 840 (2012). [link]

  1. 23.Sule, S.V., Sukumar, M., Weiss, W.F., Marcelino-Cruz, A.M., Sample, T., Tessier, P.M., "High-throughput analysis of concentration-dependent antibody self-association", Biophys. J., 101, 1749 (2011). [link]

  1. 24.Marcelino-Cruz, A.M., Bhattacharya, M., Anselmo, A., Tessier, P.M., "Site-specific structural analysis of a yeast prion strain with species-specific seeding activity", Prion, 5, 208 (2011). [link]

  1. 25.Ladiwala, A.R, Mora-Pale, M., Lin, J.C., Bale, S.S., Fishman, Z.S., Dordick, J.S., Tessier, P.M., "Polyphenolic glycosides and aglycones utilize opposing pathways to selectively remodel and inactivate toxic oligomers of amyloid β", ChemBioChem, 12, 1749 (2011). [link]

  1. 26.Perchiacca, J.M., Bhattacharya, M., Tessier, P.M., "Mutational analysis of domain antibodies reveals aggregation hotspots within and near the complementarity determining regions", Proteins, 79, 2637 (2011). [link]

  1. 27.Ladiwala, A.R., Dordick J.S., Tessier, P.M., “Aromatic small molecules remodel toxic soluble oligomers of amyloid ß through three independent pathways”, J. Biol. Chem., 286, 3209 (2011). [link]

  1. 28.Ladiwala, A.R., Lin, J.C., Bale, S.S., Marcelino-Cruz, A.M., Bhattacharya, M., Dordick, J.S., Tessier, P.M., “Resveratrol selectively remodels soluble oligomers and fibrils of amyloid Aß into off-pathway conformers”, J. Biol. Chem., 285, 24228 (2010). [link]

  1. 29.Tessier, P.M., Lindquist, S.L., "Unraveling molecular mechanisms and structures of self-perpetuating prions", in Protein Misfolding Diseases: Current and Emerging Principles and Therapies, John Wiley & Sons. Dobson, C.M., Kelly, J.W. and Ramirez-Alvarado, M. Eds., (2010).

  1. 30.Tessier, P.M., Lindquist, S.L, “Unraveling molecular interactions and structures of self-perpetuating prions and amyloids”, Nat. Struct. Mol. Biol., 16, 598 (2009). [link]

  1. 31.Bengali, A.N., Tessier, P.M., "Biospecific immobilization of proteins for rapid analysis of weak protein interactions using self-interaction nanoparticle spectroscopy", Biotechnol. Bioeng.,104, 240 (2009). [link]

  1. 32.Tessier, P.M., Jinkoji, J., Cheng, Y.-C., Prentice, J.L., Lenhoff, A.M., “Self-interaction nanoparticle spectroscopy: A nanoparticle-based protein interaction assay,” J. Am. Chem. Soc., 130, 3106 (2008). [link]

  1. 33.Tessier P.M., Lindquist S., “Prion recognition elements govern nucleation, strain specificity and species barriers,” Nature, 447, 557 (2007). [link] See accompanying commentaries in Nature, 447, 541(2007) [link], Nat. Methods, 4, 538 (2007) [link] & J. Cell Biol., 177, 747 (2007) [link].

  1. 34.Tessier, P.M., Sandler, S.I., Lenhoff, A.M., “Direct measurement of protein osmotic second virial cross coefficients by cross-interaction chromatography,” Protein Sci., 13, 1379 (2004). [link]

  1. 35.Tessier, P.M., Johnson, H.R., Pazhianur, R., Berger, B.W., Prentice, J.L., Bahnson, B.J., Sandler, S.I., Lenhoff, A.M., “Predictive crystallization of ribonuclease A via rapid screening of osmotic second virial coefficients,” Proteins, 50, 303 (2003). [link]

  1. 36.Tessier, P.M., Lenhoff, A.M., “Measurement of protein self-association as a guide to crystallization,” Curr. Opin. Biotechnol.,14, 512 (2003). [link]

  1. 37.Tessier, P.M., Verruto, V.J., Sandler, S.I., Lenhoff, A.M., “Correlation of diafiltration sieving behavior of lysozyme-BSA mixtures with osmotic second virial cross coefficients,” Biotechol. Bioeng., 87, 303 (2003). [link]

  1. 38.Tessier, P.M., Lenhoff, A.M., Sandler, S.I., “Rapid measurement of protein osmotic second virial coefficients by self-interaction chromatography,” Biophys. J., 82, 1620 (2002). [link]

  1. 39.Tessier, P.M., Vandrey, S.D., Berger, B.W., Sandler, S.I., Lenhoff, A.M., “Self-interaction chromatography: A novel screening method for rational protein crystallization,” Acta Cryst. D, 58, 1531 (2002). [link]

  1. 40.Tessier P.M., Christesen S.D., Ong K.K., Clemente E.M., Lenhoff A.M., Kaler E.W., Velev O.D., “On-line spectroscopic characterization of sodium cyanide with nanostructured gold SERS substrates,” Appl. Spectrosc., 56, 1524 (2002). [link]

  1. 41.Tessier P.M., Velev O.D., Kalambur A.T., Lenhoff A.M., Rabolt J.F., Kaler E.W., “Structured metallic films for optical and spectroscopic applications via colloidal crystal templating,” Adv. Mater., 13, 396 (2001). [link]

  1. 42.Tessier P.M., Velev O.D., Kalambur A.T., Rabolt J.F., Lenhoff A.M., Kaler E.W., “Assembly of gold nanostructured films templated by colloidal crystals and use in surface-enhanced Raman spectroscopy,” J. Am. Chem. Soc., 122, 9554 (2000). [link]

  1. 43.Velev O.D., Tessier P.M., Lenhoff A.M., Kaler E.W., “A class of porous metallic nanostructures,” Nature, 401, 548 (1999). [link]






Lab members

Open positions

Lab news:

Lab reports a nanoparticle screening method for detecting antibody aggregation in serum (Feb 2015) [link]

Tessier awarded the 2015 Biochemical Technology Young Investigator Award from the American Chemical Society (Dec 2014) [link]

Tessier named one of 30 young scientists under the age of 40 to be honored at the World Economic Forum in Tianjin, China (Sept 2014) [WEF link] [RPI link]

Tessier appointed the Richard Baruch M.D. Career Development (Endowed) Chair in Engineering (June 2014) [link]

Tessier named Review Editor for Frontiers in Molecular Biosciences (May 2014)

Tessier lab members Lilia Rabia (PhD student) and Evan Day (undergraduate student) awarded NSF Graduate Fellowships (April 2014)

Tessier awarded a Humboldt fellowship to support his research at the Max Planck Institute for Biochemistry (Mar 2014)

Lab discovers unique solubiliizing activities of positively and negatively charged mutations within the binding loops of single-domain antibodies (Jan 2014) [link]

Joe Perchiacca and Shantanu Sule (graduate students in the Tessier lab) win the 2013 Peterson Awards from the American Chemical Society (Division of Biochemical Technology) for best oral (Joe) and poster (Shantanu) presentations (Dec 2013)

Lab awarded NIH R01 to develop methods for designing antibody fragments specific for amyloid proteins (Dec 2013)

Lab publishes a review article on aggregation-resistant antibodies in Trends in Biotechnology (Aug 2013) [link]

Lab publishes an insight article on amyloid toxicity inhibitors in eLife (July 2013) [link]

Tessier named
Assistant Editor of the Journal of Biological Chemistry (April 2013)

Mark Julian (graduate student in Tessier lab) awarded an NSF Graduate Fellowship  (March 2013)

Tessier wins Rensselaer's School of Engineering Teaching Excellence Award (March 2013)

Lab reports a high-throughput method for assaying antibody stability during antibody selection in Molecular Pharmaceutics (Feb 2013) [link]

Tessier granted early tenure and will be promoted to Associate Professor in July 2013 (Dec 2012)

Lab reports a new method for designing potent antibody inhibitors of amyloid formation in PNAS (Oct 2012) [link to PNAS] [link to news story]

Lab awarded grant from NY State to develop Alzheimer’s antibodies  (Sept 2012) [link]

Kathryn Tiller (graduate student in Tessier lab) awarded an NSF Graduate Fellowship  (Sept 2012)

Lab awarded an NSF grant to develop methods for designing conformation-specific antibodies (Sept 2012) [link]

Lab reports a novel approach for engineering aggregation-resistant domain antibodies in Protein Engineering, Design & Selection (June 2012) [link]

Tessier presents the Allan P. Colburn Memorial Lecture at the University of Delaware (May 2012) [link]

Lab discovers key structural features of toxic oligomers of the Alzheimer's beta-amyloid peptide (April 2012) [link]

Tessier wins Rensselaer's Early Career Award (April 2012) [link]

Tessier wins Rensselaer's School of Engineering Research Excellence Award (April 2012) [link]

Ali Reza Ladiwala (graduate student in Tessier lab) wins Rensselaer's Karen and Lester Gerhardt Prize in Science and Engineering (April 2012)

Lab discovers that polyphenolic disaccharides are unusually effective at preventing protein aggregation (February 2012) [link]

Lab reports a motif-grafting strategy for designing conformation-specific antibodies against beta-amyloid oligomers and fibrils in PNAS (October 2011) [link to PNAS] [link to news story]

Lab reports a high-throughput, nanoparticle-based screening method for measuring monoclonal antibody self-association in Biophysical Journal (August 2011) [link]

Lab identifies structural mechanisms used by infectious prions to cross species barriers (August 2011) [link]

Lab discovers that aromatic compounds conjugated with sugars potently disaggregate toxic oligomers of beta-amyloid associated with Alzheimer's disease (June 2011) [link]

Lab identifies novel mutations that prevent antibody aggregation (May 2011) [link]

Lab awarded grant from the American Health Assistance Foundation to investigate structural differences between toxic and non-toxic oligomers of beta-amyloid associated with Alzheimer's disease (March 2011) [link]

Genetic Engineering News featured high-throughput protein self-interaction research in Tessier lab (February 2011) [link]

Lab reports three pathways used by aromatic small molecules to selectively remodel toxic soluble oligomers and fibrils of beta-amyloid in the Journal of Biological Chemistry (November 2010) [link]

Tessier wins Pew Scholars Award in Biomedical Sciences (June 2010) [link]

Lab reports that resveratrol selectively remodels toxic soluble oligomers and fibrils of beta-amyloid in the Journal of Biological Chemistry (May 2010) [link]

Tessier wins NSF CAREER Award (March 2010) [link]

Tessier & Lindquist publish a review in Nature Structural & Molecular Biology on prion structure, conformational variants and species barriers (June 2009) [link]

Lab publishes new approach for measuring weak protein interactions in Biotechnology & Bioengineering (June 2009) [link]

Lab awarded NIH grant to study the structural basis of species-specific infectivities of prion strain variants (May 2009)

Tessier awarded Alzheimer’s Association New Investigator Research Grant (July 2008) [link]

Lab publishes JACS paper on self-interaction nanoparticle spectroscopy (Feb 2008) [link]