Jimmie Wu
wuj9 at rpi.edu
Ph.D. Student (2012-)
M.S., Chemical Engineering - University of Wisconsin, Madison
Research Interests: Antibody engineering, biophysical analysis
Christine Lee
leec19 at rpi.edu
Lab news:
Tessier named an
Assistant Editor of the Journal of Biological Chemistry (April 2013)
Mark Julian (graduate student in Tessier lab) awarded an NSF Graduate Fellowship (March 2013)
Tessier wins Rensselaer's School of Engineering Teaching Excellence Award (March 2013)
Lab reports a high-throughput method for assaying antibody stability during antibody selection in Molecular Pharmaceutics (Feb 2013) [link]
Tessier granted early tenure and will be promoted to Associate Professor in July 2013 (Dec 2012)
Lab reports a new method for designing potent antibody inhibitors of amyloid formation in PNAS (Oct 2012) [link to PNAS] [link to news story]
Lab awarded grant from NY State to develop Alzheimer’s antibodies (Sept 2012) [link]
Kathryn Tiller (graduate student in Tessier lab) awarded an NSF Graduate Fellowship (Sept 2012)
Lab awarded an NSF grant to develop methods for designing conformation-specific antibodies (Sept 2012) [link]
Lab reports a novel approach for engineering aggregation-resistant domain antibodies in Protein Engineering, Design & Selection (June 2012) [link]
Tessier presents the Allan P. Colburn Memorial Lecture at the University of Delaware (May 2012) [link]
Lab discovers key structural features of toxic oligomers of the Alzheimer's beta-amyloid peptide (April 2012) [link]
Tessier wins Rensselaer's Early Career Award (April 2012) [link]
Tessier wins Rensselaer's School of Engineering Research Excellence Award (April 2012) [link]
Ali Reza Ladiwala (graduate student in Tessier lab) wins Rensselaer's Karen and Lester Gerhardt Prize in Science and Engineering (April 2012)
Lab discovers that polyphenolic disaccharides are unusually effective at preventing protein aggregation (February 2012) [link]
Lab reports a motif-grafting strategy for designing conformation-specific antibodies against beta-amyloid oligomers and fibrils in PNAS (October 2011) [link to PNAS] [link to news story]
Lab reports a high-throughput, nanoparticle-based screening method for measuring monoclonal antibody self-association in Biophysical Journal (August 2011) [link]
Lab identifies structural mechanisms used by infectious prions to cross species barriers (August 2011) [link]
Lab discovers that aromatic compounds conjugated with sugars potently disaggregate toxic oligomers of beta-amyloid associated with Alzheimer's disease (June 2011) [link]
Lab identifies novel mutations that prevent antibody aggregation (May 2011) [link]
Lab awarded grant from the American Health Assistance Foundation to investigate structural differences between toxic and non-toxic oligomers of beta-amyloid associated with Alzheimer's disease (March 2011) [link]
Genetic Engineering News featured high-throughput protein self-interaction research in Tessier lab (February 2011) [link]
Lab reports three pathways used by aromatic small molecules to selectively remodel toxic soluble oligomers and fibrils of beta-amyloid in the Journal of Biological Chemistry (November 2010) [link]
Tessier wins Pew Scholars Award in Biomedical Sciences (June 2010) [link]
Lab reports that resveratrol selectively remodels toxic soluble oligomers and fibrils of beta-amyloid in the Journal of Biological Chemistry (May 2010) [link]
Tessier wins NSF CAREER Award (March 2010) [link]
Tessier & Lindquist publish a review in Nature Structural & Molecular Biology on prion structure, conformational variants and species barriers (June 2009) [link]
Lab publishes new approach for measuring weak protein interactions in Biotechnology & Bioengineering (June 2009) [link]
Lab awarded NIH grant to study the structural basis of species-specific infectivities of prion strain variants (May 2009)
Tessier awarded Alzheimer’s Association New Investigator Research Grant (July 2008) [link]
Lab publishes JACS paper on self-interaction nanoparticle spectroscopy (Feb 2008) [link]
Lab members
Joseph Perchiacca
perchj at rpi.edu
Ph.D. Student (2008-)
B.S., Chemical Engineering - Rensselaer Polytechnic Institute
Research Interests: Antibody design, aggregation-resistant antibodies
Fanling Meng
mengf3 at rpi.edu
Postdoctoral associate (2013-)
Ph.D., Chemistry - Stony Brook Univ.
Research Interests: Inhibition of protein aggregation
Shantanu Sule
sules at rpi.edu
Ph.D. Student (2008-)
B.S., Chemical Engineering - Institute of Chemical Technology,
Mumbai, India
Research Interests: Antibody stability and aggregation, high-throughput screening
Swarnim Ranjan
ranjas at rpi.edu
Ph.D. Student (2011-)
B.Tech., Chemical Engineering - Indian Institute of Technology-Banaras Hindu University, Varanasi, India
Research Interests: Antibody design
Steven Geng
gengs at rpi.edu
Ph.D. Student (2011-)
B.Tech., Chemical Engineering - University of Maryland
Research Interests: Antibody stability and aggregation, high-throughput screening
Lab alumni
Dr. Moumita Bhattacharya (PhD 2007-2012)
Senior research scientist, Merck, moumita.bhattacharya at merck.com
Anna Marie Marcelino-Cruz (Postdoc 2008-2011)
Process scientist, Regeneron Pharmaceuticals, annamarie.cruz at regeneron.com
Jason C. Lin (MS 2007-2009)
Doctoral student, Academia Sinica, Taipei, Taiwan
Zack Fishman (Undergraduate researcher 2010-2011)
Doctoral student, Yale University
Erik Munsell (Undergraduate researcher 2010-2012)
Doctoral student, Univ. of Delaware
Bonnie Domigan (Undergraduate researcher 2010)
Doctoral student, Univ. of California, Berkeley
Aaron Anselmo (Undergraduate researcher 2009-2010)
Doctoral student, Univ. of California, Santa Barbara
Michael Zakrewsky (Undergraduate researcher 2009)
Doctoral student, Univ. of California, Santa Barbara
Aditya Bengali (Doctoral student 2008)
Process engineer, Bristol-Myers Squibb, aditya.bengali at bms.com
Mark Julian
juliam at rpi.edu
Ph.D. Student (2012-)
NSF Graduate Fellow
B.S., Chemical Engineering - Clarkson University
Research Interests: Antibody design and evolution
Kathryn Tiller
tillek at rpi.edu
Ph.D. Student (2012-)
NSF Graduate Fellow
B.S., Chemical Engineering - University of Virginia
Research Interests: Antibody design and engineering
Ph.D. Student (2012-)
B.S., Bioengineering - University of Maryland
Research Interests: Antibody stability and aggregation, high-throughput screening
Greg Nierode
nierog2 at rpi.edu
Ph.D. Student (2012-)
(co-advised with Dr. Jonathan Dordick)
B.S., Chemical Engineering - University of Colorado, Boulder
Research Interests: High-throughput screening, stem cells, amyloid toxicity
