Jiemin (Jimmie) Wu

wuj9 at rpi.edu

Ph.D. Student (2012-)

M.S., Chemical Engineering - University of Wisconsin, Madison


Research Interests: Antibody engineering, biophysical analysis

Christine Lee

leec19 at rpi.edu

Home

Tessier

Research

Publications

Lab members

Open positions


Lab news:


Tessier named one of 40 young scientists under the age of 40 to be honored at the World Economic Forum in Tianjin, China (Sept 2014)


Tessier appointed the Richard Baruch M.D. Career Development (Endowed) Chair in Engineering (June 2014)


Tessier named Review Editor for Frontiers in Molecular Biosciences (May 2014)


Tessier lab members Lilia Rabia (PhD student) and Evan Day (undergraduate student) awarded NSF Graduate Fellowships (April 2014)


Tessier awarded a Humboldt fellowship to support his research at the Max Planck Institute for Biochemistry (Mar 2014)


Lab discovers unique solubiliizing activities of positively and negatively charged mutations within the binding loops of single-domain antibodies (Jan 2014) [link]


Joe Perchiacca and Shantanu Sule (graduate students in the Tessier lab) win the 2013 Peterson Awards from the American Chemical Society (Division of Biochemical Technology) for best oral (Joe) and poster (Shantanu) presentations (Dec 2013)


Lab awarded NIH R01 to develop methods for designing antibody fragments specific for amyloid proteins (Dec 2013)


Lab publishes a review article on aggregation-resistant antibodies in Trends in Biotechnology (Aug 2013) [link]


Lab publishes an insight article on amyloid toxicity inhibitors in eLife (July 2013) [link]


Tessier named
Assistant Editor of the Journal of Biological Chemistry (April 2013)


Mark Julian (graduate student in Tessier lab) awarded an NSF Graduate Fellowship  (March 2013)


Tessier wins Rensselaer's School of Engineering Teaching Excellence Award (March 2013)


Lab reports a high-throughput method for assaying antibody stability during antibody selection in Molecular Pharmaceutics (Feb 2013) [link]


Tessier granted early tenure and will be promoted to Associate Professor in July 2013 (Dec 2012)


Lab reports a new method for designing potent antibody inhibitors of amyloid formation in PNAS (Oct 2012) [link to PNAS] [link to news story]


Lab awarded grant from NY State to develop Alzheimer’s antibodies  (Sept 2012) [link]


Kathryn Tiller (graduate student in Tessier lab) awarded an NSF Graduate Fellowship  (Sept 2012)


Lab awarded an NSF grant to develop methods for designing conformation-specific antibodies (Sept 2012) [link]


Lab reports a novel approach for engineering aggregation-resistant domain antibodies in Protein Engineering, Design & Selection (June 2012) [link]


Tessier presents the Allan P. Colburn Memorial Lecture at the University of Delaware (May 2012) [link]


Lab discovers key structural features of toxic oligomers of the Alzheimer's beta-amyloid peptide (April 2012) [link]


Tessier wins Rensselaer's Early Career Award (April 2012) [link]


Tessier wins Rensselaer's School of Engineering Research Excellence Award (April 2012) [link]


Ali Reza Ladiwala (graduate student in Tessier lab) wins Rensselaer's Karen and Lester Gerhardt Prize in Science and Engineering (April 2012)


Lab discovers that polyphenolic disaccharides are unusually effective at preventing protein aggregation (February 2012) [link]


Lab reports a motif-grafting strategy for designing conformation-specific antibodies against beta-amyloid oligomers and fibrils in PNAS (October 2011) [link to PNAS] [link to news story]


Lab reports a high-throughput, nanoparticle-based screening method for measuring monoclonal antibody self-association in Biophysical Journal (August 2011) [link]


Lab identifies structural mechanisms used by infectious prions to cross species barriers (August 2011) [link]


Lab discovers that aromatic compounds conjugated with sugars potently disaggregate toxic oligomers of beta-amyloid associated with Alzheimer's disease (June 2011) [link]


Lab identifies novel mutations that prevent antibody aggregation (May 2011) [link]


Lab awarded grant from the American Health Assistance Foundation to investigate structural differences between toxic and non-toxic oligomers of beta-amyloid associated with Alzheimer's disease (March 2011) [link]


Genetic Engineering News featured high-throughput protein self-interaction research in Tessier lab (February 2011) [link]


Lab reports three pathways used by aromatic small molecules to selectively remodel toxic soluble oligomers and fibrils of beta-amyloid in the Journal of Biological Chemistry (November 2010) [link]


Tessier wins Pew Scholars Award in Biomedical Sciences (June 2010) [link]


Lab reports that resveratrol selectively remodels toxic soluble oligomers and fibrils of beta-amyloid in the Journal of Biological Chemistry (May 2010) [link]


Tessier wins NSF CAREER Award (March 2010) [link]


Tessier & Lindquist publish a review in Nature Structural & Molecular Biology on prion structure, conformational variants and species barriers (June 2009) [link]


Lab publishes new approach for measuring weak protein interactions in Biotechnology & Bioengineering (June 2009) [link]


Lab awarded NIH grant to study the structural basis of species-specific infectivities of prion strain variants (May 2009)


Tessier awarded Alzheimer’s Association New Investigator Research Grant (July 2008) [link]


Lab publishes JACS paper on self-interaction nanoparticle spectroscopy (Feb 2008) [link]

Lab members

Ling Zhang

zhangl28 at rpi.edu

Postdoctoral associate (2014-)

Ph.D., Biochemistry and Molecular Biology - Colorado State Univ.


Research Interests: Antibody engineering, aggregation-resistant antibodies

Fanling Meng

mengf3 at rpi.edu

Postdoctoral associate (2013-)

Ph.D., Chemistry - Stony Brook Univ.


Research Interests: Antibody inhibition of protein aggregation

Steven Geng

gengs at rpi.edu

Ph.D. Student (2011-)

B.Tech., Chemical Engineering - University of Maryland


Research Interests: Antibody stability and aggregation, high-throughput screening

Lab alumni

Dr. Joseph Perchiacca (PhD 2008-2013)

Scientist, Janssen (J&J), jperchia at its.jnj.com


Dr. Shantanu Sule (PhD 2008-2013)

Senior engineer, Biogen-Idec, shantanu.sule at biogenidec.com


Dr. Ali Reza Ladiwala (PhD 2008-2012)

Process scientist, Regeneron Pharmaceuticals


Dr. Moumita Bhattacharya (PhD 2007-2012)

Senior research scientist, Merck, moumita.bhattacharya at merck.com


Dr. Anna Marie Marcelino-Cruz (Postdoc 2008-2011)

Process scientist, Regeneron Pharmaceuticals, annamarie.cruz at regeneron.com


Jason C. Lin (MS 2007-2009)

Doctoral student, Academia Sinica, Taipei, Taiwan


Zack Fishman (Undergraduate researcher 2010-2011)

Doctoral student, Yale University


Erik Munsell (Undergraduate researcher 2010-2012)

Doctoral student, Univ. of Delaware


Bonnie Domigan (Undergraduate researcher 2010)

Doctoral student, Univ. of California, Berkeley


Aaron Anselmo (Undergraduate researcher 2009-2010)

Doctoral student, NSF Graduate Research Fellow, Univ. of California, Santa Barbara


Michael Zakrewsky (Undergraduate researcher 2009)

Doctoral student, Univ. of California, Santa Barbara


Aditya Bengali (Doctoral student 2008)

Process engineer, Bristol-Myers Squibb, aditya.bengali at bms.com

Mark Julian

juliam at rpi.edu

Ph.D. Student (2012-)

NSF Graduate Fellow (2013-2016)

B.S., Chemical Engineering - Clarkson University


Research Interests: Antibody design and directed evolution

Kathryn Tiller

tillek at rpi.edu

Ph.D. Student (2012-)

NSF Graduate Fellow (2013-2016)

B.S., Chemical Engineering - University of Virginia


Research Interests: Antibody design and engineering

Ph.D. Student (2012-)

B.S., Bioengineering - University of Maryland


Research Interests: Antibody stability and aggregation, high-throughput screening

Greg Nierode

nierog2 at rpi.edu

Ph.D. Student (2012-)

(co-advised with Dr. Jonathan Dordick)

B.S., Chemical & Biological Engineering - University of Colorado, Boulder


Research Interests: High-throughput screening, stem cells, amyloid toxicity

Lilia Rabia

rabial at rpi.edu

Ph.D. Student (2013-)

NSF Graduate Fellow (2014-2017)

B.S., Chemical & Biological Engineering - University of Colorado, Boulder


Research Interests: Antibody design, directed evolution

Xiaoning Li

Postdoctoral associate (Starting July 2014)

Ph.D. student, Chemistry - UMass Amherst


Research Interests: Nanoparticle sensing, antibody stability and aggregation