2ADA: Adenosine Deaminase
The structure of Adenosine Deaminase (ADA) to the right is shown complexed with a transition state analog, 6-Hydroxyl-1,6-Dihydropurine Ribonucleoside.
On this structure, identify the following properties:
Defects of ADA activity result in "Severe Combined Immunodeficiency Disease" (SCID) because of the resultant destruction of lymphocytes. We will describe the mechanism of this effect later on, when we look at the formation of deoxynucleotides